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Gsur Lab

Ao.Univ.-Prof. Mag. Dr. Andrea Gsur

Andrea Gsur, Ao.Univ.-Prof.in Mag.a Dr.in

Research Focus

Molecular epidemiology is an emergent field in cancer research. The challenging goals of molecular epidemiology are to develop biomarkers to identify individuals at higher cancer risk and to focus cancer prevention strategies.

We have generated large biobanks comprising DNA, plasma and clinical databases from more than 18.000 cancer patients and controls. These biobanks, which represent a valuable resource for ongoing and future research projects, focus on colorectal cancer: Colorectal Cancer Study of Austria (CORSA), prostate cancer: Prostate Cancer Study of Austria (PROSA) and lung cancer: Lung Cancer Study of Austria (LUCAS).

Selected Publications

Identification of tumor tissue-derived DNA methylation biomarkers for the detection and therapy response evaluation of metastatic castration resistant prostate cancer in liquid biopsies
Dillinger, T., R. Sheibani-Tezerji, W. Pulverer, I. Stelzer, M.R. Hassler, J. Scheibelreiter, C.U. Pérez Malla, M. Kuroll, S. Domazet, E. Redl, S. Ely, S. Brezina, A. Tiefenbacher, K. Rebhan, N. Hübner, B. Grubmüller, M. Mitterhauser, M. Hacker, A. Weinhaeusel, J. Simon, M. Zeitlinger, A. Gsur, G. Kramer, S.F. Shariat, L. Kenner, G. Egger,
Mol Cancer. 2022. 21(1): p. 7. doi.10.1186/s12943-021-01445-0

Colorectal Cancer Study of Austria (CORSA): A Population-Based Multicenter Study
Gsur A, Baierl A, Brezina S
Biology. 2021 Jul 28;10(8):722. doi: 10.3390/biology10080722.

Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease
Zheng, T., D. Ellinghaus, S. Juzenas, F. Cossais, G. Burmeister, G. Mayr, I.F. Jørgensen, M. Teder-Laving, A.H. Skogholt, S. Chen, P.R. Strege, G. Ito, K. Banasik, T. Becker, F. Bokelmann, S. Brunak, S. Buch, H. Clausnitzer, C. Datz, F. Degenhardt, M. Doniec, C. Erikstrup, T. Esko, M. Forster, N. Frey, L.G. Fritsche, M.E. Gabrielsen, T. Gräßle, A. Gsur, J. Gross, J. Hampe, A. Hendricks, S. Hinz, K. Hveem, J. Jongen, R. Junker, T.H. Karlsen, G. Hemmrich-Stanisak, W. Kruis, J. Kupcinskas, T. Laubert, P.C. Rosenstiel, C. Röcken, M. Laudes, F.H. Leendertz, W. Lieb, V. Limperger, N. Margetis, K. Mätz-Rensing, C.G. Németh, E. Ness-Jensen, U. Nowak-Göttl, A. Pandit, O.B. Pedersen, H.G. Peleikis, K. Peuker, C.L. Rodriguez, M.C. Rühlemann, B. Schniewind, M. Schulzky, J. Skieceviciene, J. Tepel, L. Thomas, F. Uellendahl-Werth, H. Ullum, I. Vogel, H. Volzke, L. von Fersen, W. von Schönfels, B. Vanderwerff, J. Wilking, M. Wittig, S. Zeissig, M. Zobel, M. Zawistowski, V. Vacic, O. Sazonova, E.S. Noblin, G. Farrugia, A. Beyder, T. Wedel, V. Kahlke, C. Schafmayer, M. D'Amato, A. Franke
Gut. 2021. doi.10.1136/gutjnl-2020-323868

Untargeted Metabolomics Reveals Major Differences in the Plasma Metabolome between Colorectal Cancer and Colorectal Adenomas.
Gumpenberger T, Brezina S, Keski-Rahkonen P, Baierl A, Robinot N, Leeb G, Habermann N, Kok DEG, Scalbert A, Ueland PM, Ulrich CM, Gsur A.
Metabolites. 2021 Feb 19;11(2):119.

Genetic architectures of proximal and distal colorectal cancer are partly distinct.
Huyghe JR, Harrison TA, Bien SA, Hampel H, Figueiredo JC, Schmit SL, Conti DV, Chen S, Qu C, Lin Y, Barfield R, Baron JA, Cross AJ, Diergaarde B, Duggan D, Harlid S, Imaz L, Kang HM, Levine DM, Perduca V, Perez-Cornago A, Sakoda LC, Schumacher FR, Slattery ML, Toland AE, van Duijnhoven FJB, Van Guelpen B, Agudo A, Albanes D, Alonso MH, Anderson K, Arnau-Collell C, Arndt V, Banbury BL, Bassik MC, Berndt SI, Bézieau S, Bishop DT, Boehm J, Boeing H, Boutron-Ruault MC, Brenner H, Brezina S, Buch S, Buchanan DD, Burnett-Hartman A, Caan BJ, Campbell PT, Carr PR, Castells A, Castellví-Bel S, Chan AT, Chang-Claude J, Chanock SJ, Curtis KR, de la Chapelle A, Easton DF, English DR, Feskens EJM, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Goodman PJ, Grady WM, Grove JS, Gsur A, Gunter MJ, Haile RW, Hampe J, Hoffmeister M, Hopper JL, Hsu WL, Huang WY, Hudson TJ, Jenab M, Jenkins MA, Joshi AD, Keku TO, Kooperberg C, Kühn T, Küry S, Le Marchand L, Lejbkowicz F, Li CI, Li L, Lieb W, Lindblom A, Lindor NM, Männistö S, Markowitz SD, Milne RL, Moreno L, Murphy N, Nassir R, Offit K, Ogino S, Panico S, Parfrey PS, Pearlman R, Pharoah PDP, Phipps AI, Platz EA, Potter JD, Prentice RL, Qi L, Raskin L, Rennert G, Rennert HS, Riboli E, Schafmayer C, Schoen RE, Seminara D, Song M, Su YR, Tangen CM, Thibodeau SN, Thomas DC, Trichopoulou A, Ulrich CM, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Weigl K, Weinstein SJ, White E, Wolk A, Woods MO, Wu AH, Abecasis GR, Nickerson DA, Scacheri PC, Kundaje A, Casey G, Gruber SB, Hsu L, Moreno V, Hayes RB, Newcomb PA, Peters U.
Gut. 2021 Feb 25:gutjnl-2020-321534.

Plasma metabolites associated with colorectal cancer: A discovery-replication strategy.
Geijsen JMRA*, Brezina S*, Keski-Rahkonen P, Baierl A, Bachleitner-Hofmann T, Bergmann MM, Boehm J, Brenner H, Chang-Claude J, Duijnhoven van JBF, Gigic B, Gumpenberger T, Hofer P, Hoffmeister M, Holowatyj NA, Karner-Hanusch J, Kok ED, Leeb G, Ulvik A, Robinot N, Ose J, Stift A, Schrotz-King P, Ulrich BA, Ueland PM, Kampman E, Scalbert A, Habermann N*, Gsur A*, Ulrich MC*.
Int. J. Cancer. 2019 Jan 21. doi: 10.1002/ijc.32146.

Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms.
Schafmayer C*, Harrison JW*, Buch S*, Hofer P, Brezina S, Wedel T*, Datz C*, Gsur A*, Weedon MN*, Hampe J*.
Gut. 2019 Jan 19. doi: 10.1136/gutjnl-2018-317619.

Discovery of common and rare genetic risk variants for colorectal cancer
Huyghe JR*, Bien SA*, Harrison TA*, Brezina S, Hofer P, Gsur A, Nickerson DA*, Gruber SB*, Hsu L*, Peters U*.
Nature Genetics. 2019 Jan;51(1):76-87.

*contributed equally

All Publications

PubMed Database

Financial Support

Member of international consortia

Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)

The coordinating center for this international consortium is based at the Fred Hutchinson Cancer Research Center.
https://share.fhcrc.org/sites/gecco/Pages/background.aspx

COST Action

COST Action CA17118: "Identifiying Biomarkers Through Translational Research for Prevention and Stratification of Colorectal Cancer" (TRANSCOLONCAN)
COlorectal cancer GENeTics (COGENT):  An international consortium to study the role of polymorphic variation on the risk of colorectal cancer.
https://www.transcoloncan.eu/

COnsortium of METabolomics Studies (COMETS)

The COnsortium of METabolomics Studies (COMETS) is an extramural-intramural partnership that promotes collaboration among prospective cohort studies that follow participants for a range of outcomes and perform metabolomic profiling of individuals.
https://epi.grants.cancer.gov/comets/

PRACTICAL

Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL). The aims of the consortium, consisting of 133 different study groups, are to combine data from prostate cancer studies to provide a reliable assessment of the risks associated with these genes, and to validate new findings.
http://practical.icr.ac.uk/blog/