Mutation research is an important field of cancer research since cancer is a genetic disease of somatic cells. Our research focuses on spontaneous and induced mutagenic processes especially in non-proliferating or slowly proliferating cells. Utilizing the simple eukaryotic model organism Saccharomyces cerevisiae, we investigate the interrelation of spontaneous DNA damage and the action and regulation of different DNA repair pathways and try to elucidate the actual mutation-generating processes.
The relevance of oxidative stress and cytotoxic DNA lesions for spontaneous mutagenesis in non-replicating yeast cells
Steinboeck F, Hubmann M, Bogusch A, Dorninger P, Lengheimer T, Heidenreich E.;
Mutat Res. 2010 Jun 1;688(1-2):47-52. doi: 10.1016/j.mrfmmm.2010.03.006.
A mutation-promotive role of nucleotide excision repair in cell cycle-arrested cell populations following UV irradiation
Heidenreich E, Eisler H, Lengheimer T, Dorninger P, Steinboeck F.;
DNA Repair (Amst). 2010 Jan 2;9(1):96-100. doi: 10.1016/j.dnarep.2009.10.007
Adaptive mutation in Saccharomyces cerevisiae
Crit Rev Biochem Mol Biol. 2007 Jul-Aug;42(4):285-311.
Epistatic participation of REV1 and REV3 in the formation of UV-induced frameshift mutations in cell cycle-arrested yeast cells
Heidenreich E, Eisler H, Steinboeck F.;
Mutat Res. 2006 Jan 29;593(1-2):187-95.
Non-homologous end joining as an important mutagenic process in cell cycle-arrested cells
Heidenreich E, Novotny R, Kneidinger B, Holzmann V, Wintersberger U.
EMBO J. 2003 May 1;22(9):2274-83.