Chemical substances are not only known as relevant carcinogens but may also play an important role in the prevention of cancer.
Our reseach deals with mechanisms that are involved in such chemoprevention, which is e.g. achieved by certain coffee components.
Our research targets include beneficial effects on carcinogen metabolism, by which carcinogens may be both activated and detoxified, as well as antioxidant effects, since oxidative stress has been found to be crucial during several stages of the carcinogenic process, and stimulation of DNA-repair.
Mesenchyme-derived factors enhance preneoplastic growth by non-genotoxic carcinogens in rat liver
Nejabat M, Riegler T, Reitinger T, Subosits S, Römer M, Eichner J, Bilban M, Zell A, Huber WW, Schulte-Hermann R, Grasl-Kraupp B.
Arch Toxicol. 2018 Feb;92(2):953-966.
Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?
Waldherr M, Mišík M, Ferk F, Tomc J, Žegura B, Filipič M, Mikulits W, Mai S, Haas O, Huber WW, Haslinger E, Knasmüller S.
Arch Toxicol. 2018 Feb;92(2):921-934.
Proinflammatory mesenchymal effects of the non-genotoxic hepatocarcinogen phenobarbital: a novel mechanism of antiapoptosis and tumor promotion
Riegler T, Nejabat M, Eichner J, Stiebellehner M, Subosits S, Bilban M, Zell A, Huber WW, Schulte-Hermann R, Grasl-Kraupp B.
Carcinogenesis. 2015 Sep 16
Protective effects of coffee against induction of DNA damage and pre-neoplastic foci by aflatoxin B₁
Ferk F, Huber WW, Grasl-Kraupp B, Speer K, Buchmann S, Bohacek R, Mišík M, Edelbauer L, Knasmüller S.;
Mol Nutr Food Res. 2014 Feb; 58(2):229-38
Xanthohumol, a prenylated flavonoid contained in beer, prevents the induction of preneoplastic lesions and DNA damage in liver and colon induced by the heterocyclic aromatic amine amino-3-methyl-imidazo[4,5-f]quinoline (IQ)
Ferk F, Huber WW, Filipic M, Bichler J, Haslinger E, Misík M, Nersesyan A, Grasl-Kraupp B, Zegura B, Knasmüller S.;
Mutat Res. 2010 Sep 10; 691(1-2):17-22
Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver
Huber WW, Rossmanith W, Grusch M, Haslinger E, Prustomersky S, Peter-Vörösmarty B, Parzefall W, Scharf G, Schulte-Hermann R.;
Food Chem Toxicol. 2008 Apr; 46(4):1230-8
Thiols and the chemoprevention of cancer
Huber WW, Parzefall W.
Curr Opin Pharmacol. 2007 Aug; 7(4):404-9